Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis
نویسندگان
چکیده
منابع مشابه
Selection Acts on DNA Secondary Structures to Decrease Transcriptional Mutagenesis
Single-stranded DNA is more subject to mutation than double stranded. During transcription, DNA is transiently single stranded and therefore subject to higher mutagenesis. However, if local intra-strand secondary structures are formed, some bases will be paired and therefore less sensitive to mutation than unpaired bases. Using complete genome sequences of Escherichia coli, we show that local i...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2006
ISSN: 1553-7390,1553-7404
DOI: 10.1371/journal.pgen.0020176